Mutational signatures in squamous cell carcinoma of the lung.

ABSTRACT:

Background

Tumor mutational burden (TMB) has been identified as one of the predictors for the response to anti-programmed cell death-1 (anti-PD-1) antibody therapy and reported to correlate with smoking history in lung adenocarcinoma. However, in squamous cell carcinoma of the lung, the association between TMB and clinicopathological background factors, such as smoking history, has not been reported, including in our previous study. The mutational signature is a tool to identify the mutagens that are contributing to the mutational spectrum of a tumor by investigating the pattern of DNA changes. Here, we analyzed the mutational signature in lung squamous cell carcinoma to identify mutagens affecting the TMB.

Methods

Seven representative mutational signatures including signatu

SUBMITTER: Osoegawa A 

PROVIDER: S-EPMC7947495 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature