Correlation analysis between serum neuron-specific enolase and the detection of gene mutations in lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer is a chronic, progressive and malignant disease associated with ever-growing incidence and mortality. Targeted therapy plays an important role in the clinical treatment of lung cancer. Besides, neuron-specific enolase (NSE), an intracellular enzyme, is highly correlated with the targeted treatment outcome in patients with non-small cell lung cancer (NSCLC). The present study aimed to explore the correlation of NSE with the detection of gene mutations.

Methods

It is a case-control study. From June 2017 to October 2019, the newly diagnosed patients with lung adenocarcinoma were enrolled from the First Affiliated Hospital of Anhui Medical University. Next-generation sequencing (NGS) was conducted in these patients. Kruskal-Wallis test was used to calculat

SUBMITTER: Xu FZ 

PROVIDER: S-EPMC7947504 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature