Biodegradable metals for bone fracture repair in animal models: a systematic review.

ABSTRACT: Biodegradable metals hold promises for bone fracture repair. Their clinical translation requires pre-clinical evaluations including animal studies, which demonstrate the safety and performance of such materials prior to clinical trials. This evidence-based study investigates and analyzes the performance of bone fractures repair as well as degradation properties of biodegradable metals in animal models. Data were carefully collected after identification of population, interventions, comparisons, outcomes and study design, as well as inclusion criteria combining biodegradable metals and animal study. Twelve publications on pure Mg, Mg alloys and Zn alloys were finally included and reviewed after extraction from a collected database of 2122 publications. Compared to controls of traditional no

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7947587 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature