Zn-contained mussel-inspired film on Mg alloy for inhibiting bacterial infection and promoting bone regeneration.

ABSTRACT: Infection and insufficient osteointegration are the main causes of orthopedic implant failure. Furthermore, activating favorable inflammation response is vital to the fast osteointegration of implants. Therefore, endowing the implants with multifunctions (antibacterial, anti-inflammation, and pro-osteointegration) is a promising strategy to improve the performance of orthopedic implants. In this study, a Zn-contained polydopamine (PDA) film was fabricated on AZ31 alloy. The film possessed a stable Zn ion release in 14 days. The results of electrochemical analysis implied the favorable corrosion protection of the film, and thus, leading to a suitable hemolysis ratio (below 1%). The in vitro antibacterial assessment revealed that the film exhibited excellent resistance against Stap

SUBMITTER: Peng F 

PROVIDER: S-EPMC7947588 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature