Evaluation of Host Serum Protein Biomarkers of Tuberculosis in sub-Saharan Africa.

ABSTRACT: Accurate and affordable point-of-care diagnostics for tuberculosis (TB) are needed. Host serum protein signatures have been derived for use in primary care settings, however validation of these in secondary care settings is lacking. We evaluated serum protein biomarkers discovered in primary care cohorts from Africa reapplied to patients from secondary care. In this nested case-control study, concentrations of 22 proteins were quantified in sera from 292 patients from Malawi and South Africa who presented predominantly to secondary care. Recruitment was based upon intention of local clinicians to test for TB. The case definition for TB was culture positivity for Mycobacterium tuberculosis; and for other diseases (OD) a confirmed alternative diagnosis. Equal numbers of TB and OD pati

SUBMITTER: Morris TC 

PROVIDER: S-EPMC7947659 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature