Associations of Serum Liver Function Markers With Brain Structure, Function, and Perfusion in Healthy Young Adults.

ABSTRACT: Background: Previous neuroimaging studies have demonstrated brain abnormalities in patients with hepatic diseases. However, the identified liver-brain associations are largely limited to disease-affected populations, and the nature and extent of such relations in healthy subjects remain unclear. We hypothesized that serum liver function markers within a normal level would affect brain properties. Method: One hundred fifty-seven healthy young adults underwent structural, resting-state functional, and arterial spin labeling MRI scans. Gray matter volume (GMV), regional homogeneity (ReHo), and cerebral blood flow (CBF) analyses were performed to assess brain structure, function, and perfusion, respectively. Peripheral venous blood samples were collected to measure serum liver fu

SUBMITTER: Chen J 

PROVIDER: S-EPMC7947675 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature