Evolving Chemotherapy Free Regimens for Acute Promyelocytic Leukemia.

ABSTRACT: With the treatment advances over the last three decades, acute promyelocytic leukemia (APL) has evolved from being the most malignant form of acute leukemia to a leukemia with excellent long term survival rates. In the present review, we have summarized data leading to the development of the currently used treatment regimens for APL, which incorporate either none or minimal chemotherapeutic drugs. We have discussed the historical aspects of APL treatment along with the challenges associated with chemotherapy-based approaches and our experience with the use of single agent arsenic trioxide (ATO) which was one of the first successful, non-chemotherapy approaches used for APL. Subsequently, we have reviewed the data from major clinical trials in low-intermediate risk APL and high risk APL whi

SUBMITTER: Kulkarni U 

PROVIDER: S-EPMC7947681 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature