Common Adaptive Strategies Underlie Within-Host Evolution of Bacterial Pathogens.

ABSTRACT: Within-host adaptation is a hallmark of chronic bacterial infections, involving substantial genomic changes. Recent large-scale genomic data from prolonged infections allow the examination of adaptive strategies employed by different pathogens and open the door to investigate whether they converge toward similar strategies. Here, we compiled extensive data of whole-genome sequences of bacterial isolates belonging to miscellaneous species sampled at sequential time points during clinical infections. Analysis of these data revealed that different species share some common adaptive strategies, achieved by mutating various genes. Although the same genes were often mutated in several strains within a species, different genes related to the same pathway, structure, or function were changed in ot

SUBMITTER: Gatt YE 

PROVIDER: S-EPMC7947768 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature