Genomic Targets of Positive Selection in Giant Mice from Gough Island.

ABSTRACT: A key challenge in understanding how organisms adapt to their environments is to identify the mutations and genes that make it possible. By comparing patterns of sequence variation to neutral predictions across genomes, the targets of positive selection can be located. We applied this logic to house mice that invaded Gough Island (GI), an unusual population that shows phenotypic and ecological hallmarks of selection. We used massively parallel short-read sequencing to survey the genomes of 14 GI mice. We computed a set of summary statistics to capture diverse aspects of variation across these genome sequences, used approximate Bayesian computation to reconstruct a null demographic model, and then applied machine learning to estimate the posterior probability of positive selection in each r

SUBMITTER: Payseur BA 

PROVIDER: S-EPMC7947842 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature