Infantile Iron Deficiency Affects Brain Development in Monkeys Even After Treatment of Anemia.

ABSTRACT: A high percent of oxidative energy metabolism is needed to support brain growth during infancy. Unhealthy diets and limited nutrition, as well as other environmental insults, can compromise these essential developmental processes. In particular, iron deficiency anemia (IDA) has been found to undermine both normal brain growth and neurobehavioral development. Even moderate ID may affect neural maturation because when iron is limited, it is prioritized first to red blood cells over the brain. A primate model was used to investigate the neural effects of a transient ID and if deficits would persist after iron treatment. The large size and postnatal growth of the monkey brain makes the findings relevant to the metabolic and iron needs of human infants, and initiating treatment upon diagnosis o

SUBMITTER: Vlasova RM 

PROVIDER: S-EPMC7947927 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature