Brain Structural Network Compensation Is Associated With Cognitive Impairment and Alzheimer's Disease Pathology.

ABSTRACT:

Background

Structural network alterations in Alzheimer's disease (AD) are related to worse cognitive impairment. The aim of this study was to quantify the alterations in gray matter associated with impaired cognition and their pathological biomarkers in AD-spectrum patients.

Methods

We extracted gray matter networks from 3D-T1 magnetic resonance imaging scans, and a graph theory analysis was used to explore alterations in the network metrics in 34 healthy controls, 70 mild cognitive impairment (MCI) patients, and 40 AD patients. Spearman correlation analysis was computed to investigate the relationships among network properties, neuropsychological performance, and cerebrospinal fluid pathological biomarkers (i.e., Aβ, t-tau, and p-tau) in these subjects.

Results

AD-sp

SUBMITTER: Sheng X 

PROVIDER: S-EPMC7947929 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature