Cortical Bone Mass is Low in Boys with Klinefelter Syndrome and Improves with Oxandrolone.

ABSTRACT:

Context

Klinefelter syndrome (KS) is the most common sex aneuploidy in men. Affected males have hypogonadism, and, as a result, face an increased risk for osteoporosis and fractures. Androgen therapy is standard in adolescents and adults with KS but has not been used earlier in childhood.

Objective

To determine the effects of androgen treatment on bone mass in children with KS.

Methods

Randomized, double-blind, placebo-controlled clinical trial of oxandrolone (OX; 0.06 mg/kg daily; n = 38) versus placebo (PL; n = 40) for 2 years in boys with KS (ages 4-12 years). Changes in bone mass were examined by digital x-ray radiogrammetry, which determines the Bone Health Index (BHI) and standard deviation score (SDS).

Results

BHI SDS was similar between groups at baseli

SUBMITTER: Vogiatzi MG 

PROVIDER: S-EPMC7947965 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature