Association of Antihypertensive Drug Target Genes With Psychiatric Disorders: A Mendelian Randomization Study.

ABSTRACT:

Importance

Observational studies have reported associations between antihypertensive medication and psychiatric disorders, although the reported direction of association appears to be dependent on drug class.

Objective

To estimate the potential effect of different antihypertensive drug classes on schizophrenia, bipolar disorder, and major depressive disorder.

Design, setting, and participants

This 2-sample mendelian randomization study assessed the association between a single-nucleotide variant (SNV) and drug target gene expression derived from existing expression quantitative trait loci (eQTL) data in blood (sample 1) and the SNV-disease association from published case-control genome-wide association studies (sample 2). Significant associations were corroborated usi

SUBMITTER: Chauquet S 

PROVIDER: S-EPMC7948097 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature