Association Between Alopecia Areata and Natural Hair Color Among White Individuals.

ABSTRACT:

Importance

Alopecia areata (AA) is a complex immune-mediated disorder that causes nonscarring hair loss. Previous reports have documented preferential targeting of pigmented hair follicles with sparing of gray, nonpigmented hair follicles in alopecia lesions. Thus, immune targeting of melanogenesis-associated proteins in melanocytes and keratinocytes represents a potential mechanism for the inflammation that targets anagen hairs in alopecia areata.

Objective

To investigate the association of alopecia areata with hair color among White residents of the UK.

Design, setting, and participants

This matched, case-control study conducted in October 2020 used a large prospectively acquired cohort and included data that were collected from the UK Biobank, a large-scale prospec

SUBMITTER: Yousaf A 

PROVIDER: S-EPMC7948107 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature