Association of lymph vessel density with occult lymph node metastasis and prognosis in oral squamous cell carcinoma.

ABSTRACT:

Background

The aims of this study were to determine intra (ILVD) and peritumoral (PLVD) lymphatic vessel density (LVD), and to investigate the relationship of LVD with occult metastasis and prognosis.

Methods

Eighty-seven oral squamous cell carcinomas, in clinical stages I or II, arising in the tongue or floor of the mouth were stained with podoplanin. Lymphatic vessels were quantified in intra and peritumoral areas by sequential analysis and hot spot evaluation. Associations of the ILVD and PLVD with clinicopathologic parameters were determined by Chi-square or Fisher's exact test. The 5 and 10-year survival rates were calculated by the Kaplan-Meier and compared using the log-rank test.

Results

No significant association was observed between ILVD or PLDV and clinicop

SUBMITTER: Faustino SES 

PROVIDER: S-EPMC7948342 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature