Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient's quality of life. However, the pathogenetic mechanism of hand osteoarthritis (hand OA) is still elusive.

Methods

A genome-wide association study (GWAS) summary of hand OA was obtained from the UK Biobank dataset, which contains data from a total of 452,264 White British individuals, including 37,782 OA patients. The transcriptome-wide association study (TWAS) of hand OA was performed using FUnctional Summary-based ImputatiON (FUSION) with the skeletal muscle and blood as gene expression references. The significant genes identified by TWAS were further subjected to gene set enrichment an

SUBMITTER: Xu J 

PROVIDER: S-EPMC7948369 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature