A pan-cancer study of selenoprotein genes as promising targets for cancer therapy.

ABSTRACT:

Background

The most important health benefit of selenium (Se) is in the prevention and control of cancer. Glutathione peroxidases (GPXs) and thioredoxin reductases (TXNRDs) are selenoenzymes that are thought to play a role in oxidative stress. The differential expression of genes of the TXNRD and GPX families is closely related to carcinogenesis and the occurrence of cancer. This study comprehensively analyzed the expression profiles of seven genes in the TXNRD and GPX families, in terms of their correlations with patient survival and immune-cell subtypes, tumor microenvironment, and drug sensitivity.

Results

The expression profiles of genes in the TXNRD and GPX families differ between different types of cancer, and also between and within individual cancer cases. The expres

SUBMITTER: Wu W 

PROVIDER: S-EPMC7948377 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature