The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure.

ABSTRACT: Somatic cells can be reprogrammed into pluripotent stem cells with a minimal set of defined factors, Oct3/4, Sox2, Klf4, and c-Myc, also known as OKSM, although this reprogramming is somewhat inefficient. Recent work has identified other nuclear factors, including SALL4, that can synergize with the OSK factors to improve reprogramming dynamics, but the specific role of each of these factors remains poorly understood. In this study, we sought to learn more about the role of SALL4. We observed that SALL4 was the most significant factor in promoting OKS-induced reprogramming. To look for molecules downstream of SALL4, we screened a set of putative targets to determine whether they could promote OKS-induced reprogramming. We identified CECR2, a multidomain nuclear factor and histone acetyl-lys

SUBMITTER: Wu L 

PROVIDER: S-EPMC7948406 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature