Volatile allosteric antagonists of mosquito odorant receptors inhibit human-host attraction.

ABSTRACT: Odorant-dependent behaviors in insects are triggered by the binding of odorant ligands to the variable subunits of heteromeric olfactory receptors. Previous studies have shown, however, that specific odor binding to ORco, the common subunit of odorant receptor heteromers, may allosterically alter olfactory receptor function and profoundly affect subsequent behavioral responses. Using an insect cell-based screening platform, we identified and characterized several antagonists of the odorant receptor coreceptor of the African malaria vector Anopheles gambiae (AgamORco) in a small collection of natural volatile organic compounds. Because some of the identified antagonists were previously shown to strongly repel Anopheles and Culex mosquitoes, we examined the bioactivities of the identified an

SUBMITTER: Kythreoti G 

PROVIDER: S-EPMC7948460 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature