Identification and functional characterization of the Piezo1 channel pore domain.

ABSTRACT: Mechanotransduction is the process by which cells convert physical forces into electrochemical responses. On a molecular scale, these forces are detected by mechanically activated ion channels, which constitute the basis for hearing, touch, pain, cold, and heat sensation, among other physiological processes. Exciting high-resolution structural details of these channels are currently emerging that will eventually allow us to delineate the molecular determinants of gating and ion permeation. However, our structural-functional understanding across the family remains limited. Piezo1 is one of the largest and least understood of these channels, with various structurally identified features within its trimeric assembly. This study seeks to determine the modularity and function of Piezo1 channels

SUBMITTER: Nosyreva ED 

PROVIDER: S-EPMC7948955 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature