Endoplasmic reticulum stress in human chronic wound healing: Rescue by 4-phenylbutyrate.

ABSTRACT: During wound healing, cells have a high rate of protein synthesis and many proteins need to be folded post-translationally to function, which occurs in the endoplasmic reticulum (ER). In addition to proliferation, several cellular stress conditions, such as hypoxia, in the wound micro-environment lead to the accumulation of unfolded or misfolded proteins in the ER, causing ER stress. Eukaryotic cells have a signalling system to manage ER stress called the unfolded protein response (UPR). Mild UPR activation has a beneficial homeostatic effect; however, excessive UPR induces cell death. Herein, we examined venous leg ulcer biopsies versus normal acute incisional wounds in age-matched elderly subjects and found a large increase in ER stress markers. To study the underlying mechanism, we esta

SUBMITTER: Bachar-Wikstrom E 

PROVIDER: S-EPMC7949014 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature