Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.

ABSTRACT: The G protein-coupled receptor GPRC6A regulates various physiological processes in response to its interaction with multiple ligands, such as extracellular basic amino acids, divalent cations, testosterone, and the uncarboxylated form of osteocalcin (GluOC). Global ablation of GPRC6A increases the susceptibility of mice to diet-induced obesity and related metabolic disorders. However, given that GPRC6A is expressed in many tissues and responds to a variety of hormonal and nutritional signals, the cellular and molecular mechanisms underlying the development of metabolic disorders in conventional knockout mice have remained unclear. On the basis of our previous observation that long-term oral administration of GluOC markedly reduced adipocyte size and improved glucose tolerance in WT mice, w

SUBMITTER: Mukai S 

PROVIDER: S-EPMC7949034 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature