Bioenergetic consequences of F_oF₁-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei.

ABSTRACT: Mitochondrial ATP synthase is a reversible nanomotor synthesizing or hydrolyzing ATP depending on the potential across the membrane in which it is embedded. In the unicellular parasite Trypanosoma brucei, the direction of the complex depends on the life cycle stage of this digenetic parasite: in the midgut of the tsetse fly vector (procyclic form), the F_oF₁-ATP synthase generates ATP by oxidative phosphorylation, whereas in the mammalian bloodstream form, this complex hydrolyzes ATP and maintains mitochondrial membrane potential (ΔΨm). The trypanosome F_oF₁-ATP synthase contains numerous lineage-specific subunits whose roles remain unknown. Here, we seek to elucidate the function of the lineage-specific protein Tb1, the largest membrane-bound subu

SUBMITTER: Hierro-Yap C 

PROVIDER: S-EPMC7949148 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature