Hepatic LDL receptor-related protein-1 deficiency alters mitochondrial dynamics through phosphatidylinositol 4,5-bisphosphate reduction.

ABSTRACT: The LDL receptor-related protein 1 (LRP1) is a multifunctional transmembrane protein with endocytosis and signal transduction functions. Previous studies have shown that hepatic LRP1 deficiency exacerbates diet-induced steatohepatitis and insulin resistance via mechanisms related to increased lysosome and mitochondria permeability and dysfunction. The current study examined the impact of LRP1 deficiency on mitochondrial function in the liver. Hepatocytes isolated from liver-specific LRP1 knockout (hLrp1^-/-) mice showed reduced oxygen consumption compared with control mouse hepatocytes. The mitochondria in hLrp1^-/- mouse livers have an abnormal morphology and their membranes contain significantly less anionic phospholipids, including lower levels of phosphatidylethanol

SUBMITTER: Chinnarasu S 

PROVIDER: S-EPMC7949165 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature