IGFBP-1 and IGFBP-2 are associated with a decreased pulse-wave velocity in young, healthy adults.

ABSTRACT:

Background and aims

In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals.

Methods

We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT).

Results

Three pr

SUBMITTER: Pettersson-Pablo P 

PROVIDER: S-EPMC7949246 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature