CXCR6 deficiency impairs cancer vaccine efficacy and CD8⁺ resident memory T-cell recruitment in head and neck and lung tumors.

ABSTRACT:

Background

Resident memory T lymphocytes (T_RM) are located in tissues and play an important role in immunosurveillance against tumors. The presence of T_RM prior to treatment or their induction is associated to the response to anti-Programmed cell death protein 1 (PD-1)/Programmed death-ligand 1 (PD-L1) immunotherapy and the efficacy of cancer vaccines. Previous work by our group and others has shown that the intranasal route of vaccination allows more efficient induction of these cells in head and neck and lung mucosa, resulting in better tumor protection. The mechanisms of in vivo migration of these cells remains largely unknown, apart from the fact that they express the chemokine receptor CXCR6.

Methods

We used CXCR6-deficient mice and an intra

SUBMITTER: Karaki S 

PROVIDER: S-EPMC7949477 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature