Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.

ABSTRACT: Cells continually degrade and replace damaged proteins. However, the high energetic demand of protein turnover generates reactive oxygen species that compromise the long-term health of the proteome. Thus, the relationship between aging, protein turnover, and energetic demand remains unclear. Here, we used a proteomic approach to measure rates of protein turnover within primary fibroblasts isolated from a number of species with diverse life spans including the longest-lived mammal, the bowhead whale. We show that organismal life span is negatively correlated with turnover rates of highly abundant proteins. In comparison with mice, cells from long-lived naked mole rats have slower rates of protein turnover, lower levels of ATP production, and reduced reactive oxygen species levels. Despite h

SUBMITTER: Swovick K 

PROVIDER: S-EPMC7950207 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature