Metabolic footprint of aging and obesity in red blood cells.

ABSTRACT: Aging is a physiological process whose underlying mechanisms are still largely unknown. The study of the biochemical transformations associated with aging is crucial for understanding this process and could translate into an improvement of the quality of life of the aging population. Red blood cells (RBCs) are the most abundant cells in humans and are involved in essential functions that could undergo different alterations with age. The present study analyzed the metabolic alterations experienced by RBCs during aging, as well as the influence of obesity and gender in this process. To this end, the metabolic profile of 83 samples from healthy and obese patients was obtained by Nuclear Magnetic Resonance spectroscopy. Multivariate statistical analysis revealed differences between Age-1 (≤45)

SUBMITTER: Domingo-Orti I 

PROVIDER: S-EPMC7950240 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature