GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway.

ABSTRACT: Few studies have focused on γ-aminobutyric acid type A (GABA_A) receptor-associated protein (GABARAP) in tumor progression. We investigated the expression and importance of GABARAP in breast cancer. We analyzed the expression of GABARAP and its relationship with clinicopathological features and prognosis (TCGA). To explain the role and potential mechanism of GABARAP in regulating tumor development, we performed acquisition and loss of function experiments using cell lines and models of mouse xenotransplantation. We found that GABARAP inhibited proliferation, migration and invasion in vitro and in vivo. Notably, low levels of GABARAP induced the epithelial-mesenchymal transition (EMT). Low levels of GABARAP increased p-AKT and p-mTOR levels, and a specific AKT pathwa

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7950252 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature