Cell differentiation trajectory predicts patient potential immunotherapy response and prognosis in gastric cancer.

ABSTRACT: The purpose of this study was to investigate the differentiation trajectory of gastric cancer (GC) cells and its clinical relevance and generate a prognostic risk scoring (RS) signature based on GC differentiation-related genes (GDRGs) to predict overall survival (OS). Integrated single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data from GC samples were used for analysis. The cell differentiation trajectory analysis identified three subsets with distinct differentiation states, of which subsets I/II were involved in metabolic disorders, subset II were also associated with hypoxia tolerance, and subset III were related to immune-related pathways. GC samples were divided into three GDRG-based molecular subtypes, and it was found that molecular typing based on cell differentiation succ

SUBMITTER: Xiang R 

PROVIDER: S-EPMC7950306 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature