Phthalate pregnancy exposure and male offspring growth from the intra-uterine period to five years of age.

ABSTRACT:

Objective

To study associations between prenatal exposure to phthalates and fetal and postnatal growth up to age 5 years in male offspring.

Methods

Eleven phthalate metabolites were quantified in spot maternal urine samples collected during gestation among 520 women of the EDEN mother-child cohort who gave birth to a boy. Fetal growth was assessed from repeated ultrasound measurements and measurements at birth. We used repeated measures of weight and height in the first 5 years of life to model individual postnatal growth trajectories. We estimated adjusted variations in pre and postnatal growth parameters associated with an interquartile range increase in ln-transformed phthalate metabolite concentrations.

Results

Monocarboxyisononyl phthalate (MCNP) was positively a

SUBMITTER: Botton J 

PROVIDER: S-EPMC7950638 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature