Deficient Active Transport Activity in Healing Mucosa After Mild Gastric Epithelial Damage.

ABSTRACT:

Background

Peptic ulcers recur, suggesting that ulcer healing may leave tissue predisposed to subsequent damage. In mice, we have identified that the regenerated epithelium found after ulcer healing will remain abnormal for months after healing.

Aim

To determine whether healed gastric mucosa has altered epithelial function, as measured by electrophysiologic parameters.

Method

Ulcers were induced in mouse gastric corpus by serosal local application of acetic acid. Thirty days or 8 months after ulcer induction, tissue was mounted in an Ussing chamber. Transepithelial electrophysiologic parameters (short-circuit current, I_sc. resistance, R) were compared between the regenerated healed ulcer region and the non-ulcerated contralateral region, in response to lumi

SUBMITTER: Matthis AL 

PROVIDER: S-EPMC7950857 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature