The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial.

ABSTRACT:

Background

Uromodulin modulates the sodium-potassium-two-chloride transporter in the thick ascending limb of the loop of Henle, and its overexpression in murine models leads to salt-induced hypertension. We hypothesized that individuals with higher baseline levels of urine uromodulin would have a greater increase in systolic blood pressure (SBP) for the same increase in sodium compared with those with lower uromodulin levels.

Methods

We used data from 157 subjects randomized to the control diet of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial who were assigned to 30 days of low (1,500 mg/d), medium (2,400 mg/d), and high salt (3,300 mg/d) diets in random order. Blood pressure was measured prerandomization and then weekly during each feeding period. We evalu

SUBMITTER: Bakhoum CY 

PROVIDER: S-EPMC7951043 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature