Dynamics of pseudo-atrophy in RRMS reveals predominant gray matter compartmentalization.

ABSTRACT:

Objective

To assess the dynamics of "pseudo-atrophy," the accelerated brain volume loss observed after initiation of anti-inflammatory therapies, in patients with multiple sclerosis (MS).

Methods

Monthly magnetic resonance imaging (MRI) data of patients from the IMPROVE clinical study (NCT00441103) comparing relapsing-remitting MS patients treated with interferon beta-1a (IFNβ-1a) for 40 weeks versus those receiving placebo (16 weeks) and then IFNβ-1a (24 weeks) were used to assess percentage of gray (PGMVC) and white matter (PWMVC) volume changes. Comparisons of PGMVC and PWMVC slopes were performed with a mixed effect linear model. In the IFNβ-1a-treated arm, a quadratic term was included in the model to evaluate the plateauing effect over 40 weeks.

Results

Up to we

SUBMITTER: De Stefano N 

PROVIDER: S-EPMC7951094 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature