HCMV infection and IFITM3 rs12252 are associated with Rasmussen's encephalitis disease progression.

ABSTRACT:

Objective

Rasmussen's encephalitis (RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses such as human cytomegalovirus (HCMV) has been hypothesized to be a potential trigger for RE. Interferon-induced transmembrane protein-3 (IFITM3) single-nucleotide polymorphism (SNP) rs12252 is associated with the severity of viral infection disease. This study aimed to address the possibility that HCMV infection and IFITM3 rs12252 might be associated with RE disease progression.

Methods

The expression of HCMV and IFITM3 was detected with immunohistochemical staining, in situ hybridization and immunofluorescence double staining. The genotype of IFITM3 rs12252 was detected using the Sanger sequencing method. A genetic association analysis was

SUBMITTER: Wang YS 

PROVIDER: S-EPMC7951106 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature