Interleukin 7 receptor is required for myeloid cell homeostasis and reconstitution by hematopoietic stem cells.

ABSTRACT: Respiratory diseases are a leading cause of death worldwide, with vulnerability to disease varying greatly between individuals. The reasons underlying disease susceptibility are unknown, but there is often a variable immune response in lungs often. Recently, we identified a surprising novel role for the interleukin 7 receptor (IL7R), a primarily lymphoid-associated regulator, in fetal-specified, lung-resident macrophage development. Here, we report that traditional, hematopoietic stem cell-derived myeloid cells in the adult lung, peripheral blood, and bone marrow also depend on IL7R expression. Using single- and double-germline knockout models, we found that eosinophil numbers were reduced on deletion of IL7Rα. We then employed two Cre recombinase models in lineage tracing experiments to t

SUBMITTER: Cool T 

PROVIDER: S-EPMC7951140 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature