The effect of conditioning stimulus intensity on conditioned pain modulation (CPM) hypoalgesia.

ABSTRACT: Background: The magnitude and duration of conditioned pain modulation (CPM) likely depends on the nature and intensity of the conditioning stimulus (CS). Aims: The aim of this study was to measure the effect of CS intensity on the duration of CPM hypoalgesia. Methods: In this single-blind, nonrandomized, repeated measures study, we assessed CPM hypoalgesia in 20 healthy participants following cold pressor tests (CPT) at 7°C and 12°C. The test stimulus, a 60-s heat stimulation, was administered before the CPT and immediately after, and again at 5-min intervals until participants' pain scores returned to pre-CS levels. Two hypoalgesia thresholds were used to establish return to pre-CS level: within -10/100 of baseline and within -20/100 of baseline. Results: CPM h

SUBMITTER: Coulombe-Leveque A 

PROVIDER: S-EPMC7951153 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature