Probing in vivo cortical myeloarchitecture in humans via line-scan diffusion acquisitions at 7 T with 250-500 micron radial resolution.

ABSTRACT:

Purpose

The goal of this study was to measure diffusion signals within the cerebral cortex using the line-scan technique to achieve extremely high resolution in the radial direction (ie, perpendicular to the cortical surface) and to demonstrate the utility of these measurements for investigating laminar architecture in the living human brain.

Methods

Line-scan diffusion data with 250-500 micron radial resolution were acquired at 7 T on 8 healthy volunteers, with each line prescribed perpendicularly to primary somatosensory cortex (S1) and primary motor cortex (M1). Apparent diffusion coefficients, fractional anisotropy values, and radiality indices were measured as a function of cortical depth.

Results

In the deep layers of S1, we found evidence for high anisotropy an

SUBMITTER: Balasubramanian M 

PROVIDER: S-EPMC7951328 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature