The Proximal Airway Is a Reservoir for Adaptive Immunologic Memory in Idiopathic Subglottic Stenosis.

ABSTRACT:

Objectives/hypothesis

Characterization of the localized adaptive immune response in the airway scar of patients with idiopathic subglottic stenosis (iSGS).

Study design

Basic Science.

Methods

Utilizing 36 patients with subglottic stenosis (25 idiopathic subglottic stenosis [iSGS], 10 iatrogenic post-intubation stenosis [iLTS], and one granulomatosis with polyangiitis [GPA]) we applied immunohistochemical and immunologic techniques coupled with RNA sequencing.

Results

iSGS, iLTS, and GPA demonstrate a significant immune infiltrate in the subglottic scar consisting of adaptive cell subsets (T cells along with dendritic cells). Interrogation of T cell subtypes showed significantly more CD69⁺ CD103⁺ CD8⁺ tissue resident memory T cel

SUBMITTER: Gelbard A 

PROVIDER: S-EPMC7951501 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature