Early detection of complications in pancreas transplants by microdialysis catheters, an observational feasibility study.

ABSTRACT:

Background

Despite advances in immunosuppression and surgical technique, pancreas transplantation is encumbered with a high rate of complication and graft losses. Particularly, venous graft thrombi occur relatively frequently and are rarely detected before the transplant is irreversibly damaged.

Methods

To detect complications early, when the grafts are potentially salvageable, we placed microdialysis catheters anteriorly and posteriorly to the graft in a cohort of 34 consecutive patients. Glucose, lactate, pyruvate, and glycerol were measured at the bedside every 1-2 hours.

Results

Nine patients with graft venous thrombosis had significant lactate and lactate-to-pyruvate-ratio increases without concomitant rise in blood glucose or clinical symptoms. The median lactat

SUBMITTER: Kjosen G 

PROVIDER: S-EPMC7951931 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature