Mitochondrial DNA haplogroups and weight gain following switch to integrase strand transfer inhibitor-based antiretroviral therapy.

ABSTRACT:

Background

Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) has been associated with excess weight gain in some adults, which may be influenced by genetic factors. We assessed mitochondrial DNA (mtDNA) haplogroups and weight gain following switch to INSTI-based ART.

Methods

All AIDS Clinical Trials Group A5001 and A5322 participants with mtDNA genotyping who switched to INSTI were included. mtDNA haplogroups were derived from prior genotyping algorithms. Race/ethnicity-stratified piecewise linear mixed effects models assessed the relationship between mtDNA haplogroup and weight change slope differences before and after switch to INSTI.

Results

A total of 291 adults switched to INSTI: 78% male, 50% non-Hispanic White, 28% non-Hispanic Blac

SUBMITTER: Erlandson KM 

PROVIDER: S-EPMC7951953 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature