Public Baseline and shared response structures support the theory of antibody repertoire functional commonality.

ABSTRACT: The naïve antibody/B-cell receptor (BCR) repertoires of different individuals ought to exhibit significant functional commonality, given that most pathogens trigger an effective antibody response to immunodominant epitopes. Sequence-based repertoire analysis has so far offered little evidence for this phenomenon. For example, a recent study estimated the number of shared ('public') antibody clonotypes in circulating baseline repertoires to be around 0.02% across ten unrelated individuals. However, to engage the same epitope, antibodies only require a similar binding site structure and the presence of key paratope interactions, which can occur even when their sequences are dissimilar. Here, we search for evidence of geometric similarity/convergence across human antibody repertoires. We firs

SUBMITTER: Raybould MIJ 

PROVIDER: S-EPMC7951972 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature