Longitudinal relationships of cytokines, depression and anhedonia in depressed adolescents.

ABSTRACT:

Background

Depression has been associated with low-grade elevation of plasma cytokines (e.g. interleukin-6, IL-6; tumor necrosis factor alpha, TNFα) in both cross-sectional and longitudinal studies in adults. Preclinical and clinical studies also suggest that IL-6 and TNFα elevation are associated with anhedonia. However, few studies have examined longitudinal relationships between cytokines and depression/anhedonia in clinically depressed samples, particularly adolescents.

Methods

Thirty-six adolescents with a depressive disorder receiving standard-of-care community treatment were assessed at a baseline and a follow-up timepoint. Self-report and clinical measures of depression and anhedonia, along with plasma IL-6 and TNFα levels, were obtained at both timepoints. Baseline

SUBMITTER: Rengasamy M 

PROVIDER: S-EPMC7952030 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature