Electrical and Hemodynamic Neural Functions in People With ALS: An EEG-fNIRS Resting-State Study.

ABSTRACT:

Objective

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that causes the progressive loss of voluntary muscle control. Recent studies have reported conflicting results on alterations in resting-state functional brain networks in ALS by adopting unimodal techniques that measure either electrophysiological or vascular-hemodynamic neural functions. However, no study to date has explored simultaneous electrical and vascular-hemodynamic changes in the resting-state brain in ALS. Using complementary multimodal electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recording and analysis techniques, we explored the underlying multidimensional neural contributions to altered oscillations and functional connectivity in people with ALS.

SUBMITTER: Deligani RJ 

PROVIDER: S-EPMC7952040 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature