Dose Tapering of Biologics in Patients with Psoriasis: A Scoping Review.

ABSTRACT:

Introduction

Biologics serve as a cornerstone in psoriasis treatment, with low disease activity or sometimes even clinical remission as a realistic treatment outcome. So far, it is unclear whether biologics should be tapered when this target is achieved. Dose tapering could offer potential benefits by decreasing side effects, the burden of repetitive injections and costs of biological therapy. However, clinical guidelines on dose tapering of biologicals in psoriasis patients are lacking. This scoping review was conducted to provide an overview of the current literature on dose tapering and offer guidance for clinicians in daily clinical practice.

Methods

Dose tapering is defined as the administration of a lower dose per administration, or the prolongation of the regular dose

SUBMITTER: Michielsens CAJ 

PROVIDER: S-EPMC7952351 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature