Haloperidol, clonidine and resolution of delirium in critically ill patients: a prospective cohort study.

ABSTRACT:

Purpose

Haloperidol and clonidine are commonly used to treat agitation in delirious intensive care unit (ICU) patients, but it is unclear whether these agents may shorten the duration of delirium. The objective of this study was to determine whether haloperidol, clonidine, or their combined administration to delirious ICU patients results in delirium resolution.

Methods

This was a cohort study on a mixed ICU, excluding patients with a primary neurological disorder. The main outcome was the probability of delirium resolution, using propensity score matching and Markov multinomial logistic regression models for daily transitions. Secondary outcomes were delirium duration, number of delirium days, ventilation days, length of stay in the ICU and hospital, and ICU mortality.

R

SUBMITTER: Smit L 

PROVIDER: S-EPMC7952362 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature