Nonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety.

ABSTRACT: Anxiety disorders are among the most prevalent psychiatric disorders, causing significant suffering and disability. Behavioral inhibition is a temperament that is linked to an increased risk for the later development of anxiety disorders and other stress-related psychopathology, and understanding the neural systems underlying this dispositional risk could provide insight into novel treatment targets for anxiety disorders. Nonhuman primates (NHPs) have anxiety-related temperaments that are similar to those of humans with behavioral inhibition, facilitating the design of translational models related to human psychopathology. Characterization of our NHP model of behavioral inhibition, which we term anxious temperament (AT), reveals that it is trait-like. Exploration of the neural substrates o

SUBMITTER: Kenwood MM 

PROVIDER: S-EPMC7952470 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature