Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysis.

ABSTRACT:

Background

The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly spread worldwide. Researchers are trying to find a way to treat this disease as soon as possible. The present study aimed to identify the genes involved in COVID-19 and find a new drug target therapy. Currently, there are no effective drugs targeting SARS-CoV-2, and meanwhile, drug discovery approaches are time-consuming and costly. To address this challenge, this study utilized a network-based drug repurposing strategy to rapidly identify potential drugs targeting SARS-CoV-2. To this end, seven potential drugs were proposed for COVID-19 treatment using protein-protein interaction (PPI) network analysis. First, 524 proteins in humans that have interaction with the SARS-CoV-2 virus were collected, a

SUBMITTER: Adhami M 

PROVIDER: S-EPMC7952507 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature