PHIP hyperpolarized [1-¹³C]pyruvate and [1-¹³C]acetate esters via PH-INEPT polarization transfer monitored by ¹³C NMR and MRI.

ABSTRACT: Parahydrogen-induced polarization of ¹³C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-¹³C]acetate and [1-¹³C]pyruvate esters with application of PH-INEPT-type pulse sequences for ¹H to ¹³C polarization transfer is reported, and its efficiency is compared with that of polarization transfer based on magnetic field cycling (MFC). The pulse-sequence transfer approach may have its merits in some applications because the entire hyperpolarization procedure is implemented directly in an NMR or MRI instrument, whereas MFC requires a controlled field variation at low magnetic fields. Optimization of the PH-INEPT-type transfer sequences resulted in ¹³C polarization values of 0.66 ± 0.04% and 0.19 ± 0.02% for allyl [1-¹³

SUBMITTER: Svyatova A 

PROVIDER: S-EPMC7952547 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature