Elevated levels of mitochondrial CoQ₁₀ induce ROS-mediated apoptosis in pancreatic cancer.

ABSTRACT: Reactive oxygen species (ROS) are implicated in triggering cell signalling events and pathways to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death allows for targeting ROS pathways for effective anti-cancer therapeutics. Coenzyme Q₁₀ is a critical cofactor in the electron transport chain with complex biological functions that extend beyond mitochondrial respiration. This study demonstrates that delivery of oxidized Coenzyme Q₁₀ (ubidecarenone) to increase mitochondrial Q-pool is associated with an increase in ROS generation, effectuating anti-cancer effects in a pancreatic cancer model. Consequent activation of cell death was observed in vitro in pancreatic cancer cells, and both human patient-derived organoids and tu

SUBMITTER: Dadali T 

PROVIDER: S-EPMC7952582 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature